Amikacin (Draft)¶
PD Dialyzability: Likely
Pharmacokinetic Parameters [1] [2] [3] [4]¶
| Amikacin | |
|---|---|
| Molecular Weight (Da) | 586 |
| Plasma Protein Binding (%) | <5 |
| Volume of Distribution (L/Kg) | 0.22-0.29 |
| Hepatic Metabolism | Mostly excreted renally unchanged |
| Excreted Unchanged (%) | 95 |
| Half-Life; Normal Renal Function (hours) | 1.4-2.3 |
| Half-Life; ESRD (hours) | 17-150 |
References¶
| [1] | Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, et al. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D668-672. |
| [2] | American Pharmacists Association. Drug information handbook: a comprehensive resource for all clinicians and healthcare professionals. Hudson, Ohio; [Washington, D.C.: Lexi-Comp ; American Pharmacists Association; 2012. |
| [3] | Aronoff GR, editor. Drug prescribing in renal failure: dosing guidelines for adults and children. 5. ed. Philadelphia, Pa: American College of Physicians; 2007. |
| [4] | Gilbert B, Robbins P, Livornese LL. Use of Antibacterial Agents in Renal Failure. Medical Clinics of North America. 2011 Jul;95(4):677–702. |